2. Signalwege
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-101674
    Tiapamil hydrochloride
    		Antagonist
    Tiapamil hydrochloride is a calcium channel blocker.
    Tiapamil hydrochloride
  • HY-101685
    Iganidipine
    		Antagonist
    Iganidipine is a Ca2+ antagonist.
    Iganidipine
  • HY-19062
    SM-6586
    		Antagonist
    SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
    SM-6586
  • HY-101669
    TDN345
    		Antagonist
    TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.
    TDN345
  • HY-167168
    (S)-Azelnidipine
    		Antagonist
    (S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research.
    (S)-Azelnidipine
  • HY-120180
    BMS-188107
    		Antagonist
    BMS-188107 is a calcium antagonist that exerts anti-ischemic effects. BMS-188107 improves postischemic contractile function and reduces lactate dehydrogenase release. BMS-188107 can be utilized in cardiovascular research.
    BMS-188107
  • HY-B0549AS
    Flavoxate-d4 (hydrochloride)
    		Antagonist
    Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.
    Flavoxate-d<sub>4</sub> (hydrochloride)
  • HY-W037193
    Calcium Channel antagonist 5
    		Antagonist
    Calcium Channel antagonist 5 (compound 32) is a calcium channel antagonist with a pIC50 of 5.50.
    Calcium Channel antagonist 5
  • HY-U00354
    CP-060
    		Antagonist
    CP-​060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.
    CP-060
  • HY-U00151
    Dopropidil
    		Antagonist
    Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
    Dopropidil
  • HY-U00086
    Darodipine
    		Antagonist
    Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
    Darodipine
  • HY-U00284
    AE0047 Hydrochloride
    		Antagonist
    AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.
    AE0047 Hydrochloride
Art. -Nr. Produktname / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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